Under normoxic conditions, the levels of mRNA encoding PDK1 and PDHA1 were significantly increased in PAH-PASMCs compared with non-PAH-PASMCs by factors of 2.0-fold (p < 0.05) and 3.1-fold (p < 0.01), respectively (Figure 1A,B). The gene discussed is PDK1; the disease is pulmonary arterial hypertension.