AGT and hypertensive disorder: On the other hand, under pathological conditions, such as obesity, diabetes, and hypertension, PVAT is also able to produce pro-inflammatory cytokines (IL-6, TNF-alpha, IL-8, MCP-1, TGF-Beta), prothrombotic factors (PAI-1), and vasoconstriction molecules, such as endothelin-1 and angiotensin II [48].