ADAMTS13 and thrombotic thrombocytopenic purpura: Another randomized clinical trial examining the adjunct use of prednisone versus cyclosporine to TPE was halted after interim analysis (22 total evaluable patients) showed an increase in exacerbations with the latter strategy during acute immune TTP treatment, in addition to prednisone significantly improving ADAMTS13 activity at weeks 3 and 4 and lowering anti-ADAMTS13 IgG at weeks 2–4 compared to cyclosporine [33].