With this in mind, and since IMT504 has both immunomodulatory and regenerative properties, our group started to evaluate this ODN as a possible therapy for T1D in several animal models, finding very promising results in terms of beta cell recovery, improvement on glucose and insulin blood levels, and decrease in beta cell apoptosis, and insulitis and infiltration of CD45+ leukocytes into the pancreas (Bianchi et al., 2010, 2012, 2016, 2021). The gene discussed is PTPRC; the disease is type 1 diabetes mellitus.