Interestingly, patient primary samples when positive, demonstrated diffuse continuous staining (cytoplasmic and membrane) in the cancer component that was ubiquitous and homogeneous in intensity (Fig. 3A, B), unlike ADAM8 staining in cell lines (Fig. 1C) or PDX samples (Fig. 2C, D), which was more heterogeneous. The gene discussed is ADAM8; the disease is cancer.