ADAM8 and cancer: For example, in gastric cancers, the 4th leading cancer-related cause of death globally (WHO), two studies reported higher levels of ADAM8 mRNA in tumor vs adjacent normal tissue; furthermore, high ADAM8 expression was identified as an independent predictor of poor prognosis, correlating with shorter survival at 3-years (52% vs 82%) and 5-years (31% vs 67%) post-diagnosis [5, 15].