At least one of the four algorithms that met the criteria for significant SOCs related to rucaparib were general disorders and administration site conditions (SOC: 10018065, 4,052), gastrointestinal disorders (SOC: 10017947, 3,387), investigations (SOC: 10022891, 2,435), nervous system disorders (SOC: 10029205, 1,947), metabolism and nutrition disorders (SOC: 10027433, 1,068), cardiac disorders (SOC: 10007541, 980), musculoskeletal and connective tissue disorders (SOC: 10028395, 919), and blood and lymphatic system disorders (SOC: 10005329, 855). The gene discussed is CISH; the disease is lymphatic system disorder.