In conclusion, our study elucidated that TQ mitigated hyperlipidemia-induced liver injury as indicated by the suppression of metabolic characteristics (TC, TG, and LDL-c), liver biochemical parameters (ALT, AST, and ALP), pyroptosis indicators (NLRP3, IL-1β, and IL-18), a macrophage marker (CD68), and the PI3K signaling pathway. This evidence concerns the gene IL18 and hyperlipidemia.