PD-L1(PDCD1), CTLA4 and PD1 (CD274) are important immune checkpoints which are in charge of tumor immune escape.Taken the potential carcinogenic function of HHIP in CRC into consideration, the correlation of HHIP with PD-L1, CTLA4 and PD1 was assessed. This evidence concerns the gene CTLA4 and neoplasm.