As shown in Fig. 1A, compared with normal samples, HHIP was significantly downregulated in 20 cancer types, including ACC, BLCA, BRCA, CESC, CHOL, COAD, GBM, KICH, KIRC, KIRP, LGG, LIHC, LUAD, LUSC, OV, PCPG, SKCM, STAD, TGCT and THCA. Here, HHIP is linked to cancer.