Significant differences were observed in Dukes stage, degree of differentiation, lymph node metastasis, CEA, Alb and D-dimer between patients with liver metastasis and patients without liver metastasis (P < 0.05), but there existed no significant differences in gender, age, maximum tumor diameter, histological type and CA199 between two groups (P > 0.05, Table 3). The gene discussed is ALB; the disease is neoplasm.