Netrin-1 can promote tumor cell proliferation, invasion and metastasis, and its receptor colon cancer deletion gene is one of the markers of the CRC progression and metastasis, thus it is speculated that Netrin-l may participate in the occurrence and development of CRC by regulating the expression and function of its receptor colon cancer deletion gene [30]. This evidence concerns the gene NTN1 and malignant colon neoplasm.