In the present study, Logistic regression analysis showed that Dukes stage, differentiation degree, lymph node metastasis, CEA, Alb, D-dimer, and positive expression of PLAC1 and Netrin-1 were the independent risk factors for liver metastasis of CRC, which indicated that positive expression of PLAC1 and Netrin-1 and clinicopathological features jointly promoted the occurrence of liver metastasis of colorectal cancer. The gene discussed is NTN1; the disease is colorectal cancer.