The results of this study showed that patients in metastatic group had much higher positive expression of Netrin-1 than the patients in non-metastatic group and in normal colorectal epithelial mucosa group, indicating that PLAC1 and Netrin-1 had the value of screening CRC patients with high liver metastasis tendency, played a key role in promoting tumor growth, invasion and distant metastasis in tumor progression, and had the potential of new tumor markers. The gene discussed is PLAC1; the disease is neoplasm.