PLAC1 is expressed in nucleus in the early stage of CRC, and trophoblast cells invade the endometrium accompanied with the formation of blood vessels during embryo implantation, which is very similar to the growth, migration, and invasion of CRC, and both trophoblast cells and CRC tumor cells express PLAC1 [19]. The gene discussed is PLAC1; the disease is colorectal carcinoma.