Among these m6A regulators, METTL3, CBLL1, METTL16, WTAP, VIRMA, RBM15, RBM15B, ZC3H13, YTHDC1, YTHDF1/2, EIF3B, HNRNPC, FMR1, HNRNPA2B1, LRPPRC, IGF2BP1/2/3, ELAVL1, RBMX and FTO showed higher expression in COAD tumor tissues, while the expression of ALKBH5 was lower. The gene discussed is METTL3; the disease is colon adenocarcinoma.