ALKBH5 and cancer: We observed that the expression of m6A regulators except for ALKBH5, was significantly upregulated in cluster B patients who had worse clinical outcome than those in cluster A. To gain insight into the underlying biological molecular mechanism of these two clusters, we performed GSVA and ssGSEA analyses and found that in cluster B, several carcinogenic activation pathways, such as TGF-β signaling pathway, pathway in cancer, basal cell carcinoma were enriched, indicating that these pathways might contribute to the poor survival in this group.