Tumor CGP cases were initially filtered by the presence of short variants (SV) including single nucleotide variants (SNV) and short insertions/deletions (indels) in 24 select CSGs: ATM, BAP1, BRCA1, BRCA2, BRIP1, CHEK2, FH, FLCN, MLH1, MSH2, MSH6, MUTYH, PALB2, PMS2, POLE, RAD51C, RAD51D, RET, SDHA, SDHB, SDHC, SDHD, TSC2, and VHL. The decision regarding which CSGs to include in this list was informed by review of published guidelines from the European Society of Medical Oncology Precision Medicine Working Group (ESMO PMWG)6 and the American College of Medical Genetics (ACMG)7 (Table 1). The gene discussed is MSH2; the disease is neoplasm.