MUTYH and colorectal carcinoma: Indeed, a recent publication exploring a cohort of patients with biallelic MUTYH pathogenic germline variants detected through multi-gene panel testing reported phenotypic variability in MAP, e.g., a small population of patients with no personal history of CRC or polyps (8.5%, 7/82) and extracolonic cancers reported in 26% (21/82) of individuals42.