Lastly, PPGVs identified in BRCA1/2, and other homologous recombination repair (HRR) pathway CSGs in BRCA-associated cancers (Fig. 2c) as well as MMR pathway CSGs (MLH1, MSH2, MSH6, PMS2) in Lynch Syndrome-associated cancers (Fig. 2d) were examined. The gene discussed is BRCA1; the disease is cancer.