Analysis of germinal DNA of patients revealed abundance of runs of homozygosity (RoH) in patients 1–3 (27–65 Mbp per individual) including RoH overlapping XPC, and a causative founder homozygous germline mutation typical for the studied Northern African XP-C population (delTG, XPC p.V548fs). This evidence concerns the gene XPC and xeroderma pigmentosum.