The first patient (Patient 33) is a 63-year-old Chinese male who was diagnosed with lung adenocarcinoma accompanied by mediastinal lymph node metastasis and double lung metastasis with a rare PRDX1-NTRK1 fusion (Fig. 3a) and an MTOR E2419D mutation. Here, PRDX1 is linked to metastatic malignant neoplasm in the lymph nodes.