Tim-3 expression by monocytes/macrophages may also be an important mechanism in gastric cancer progression, as Gal-9/Tim-3 signaling can significantly stimulate monocytes to secrete IL-6, IL-8, and IL-10, the expression of which in the tumor microenvironment is strongly associated with poor treatment outcome [113, 114]. This evidence concerns the gene LGALS9 and neoplasm.