AKT1 and breast carcinoma: Previous researches demonstrated that TAX could suppress the tumor cells growth in many types of cancer, such as breast carcinoma, colon carcinoma, cervix carcinoma, ovary carcinoma, and gastric cancer via multiple signaling pathway, including EGFR/AKT129 and PI3K/AKT signaling pathway36 to attenuate the progression of cancer26–29.