The cytoplasmic tail (CT) of cell-anchored mucins is believed to participate in signal transduction associated with physiological processes of the cancer cell by its phosphorylation and association with cytoskeletal elements and recruitment of cytosolic adapter proteins21.Furthermore, the significance of MUC16 as a therapeutic target is further underscored by the development of antibody-drug conjugate (ADC) and bispecific antibodies (bsAbs) for ovarian cancer22–24. Here, MUC16 is linked to cancer.