JAK2 and pachyonychia congenita: Recent studies expound a prominent role of MUC16 and their isoforms in eliciting tumorigenic characteristics and augmenting metastatic propensity of PC and NSCLC cancer cells, predominantly through interactions with focal adhesion kinase (FAK), EGFR, or altered cell adhesion through JAK2/STAT1, JAK2/STAT3 or Neuropilin-2 (NRP-2) axis18–20.