Further supporting our proposed mechanism, N-cadherin levels were high in MUC16-high tumor sections with a strong positive correlation of N-cadherin and MUC16 expression in primary PC tumors (P = 0.002, r = 0.84) (Fig. 7a) and metastatic samples (P = 7.78e–13, r = 0.99) (Fig. 7b). The gene discussed is CDH2; the disease is pachyonychia congenita.