PTK2 and cancer: Overall, a comprehensive analysis suggests that ch5E6 binding to surface-anchored MUC16-Cter domain intervenes with onco-MUC16 CT associated signaling as seen by reductions in FAK and p70S6K phosphorylation and N-cadherin downregulation which further leads to a considerable reduction of cancer cell proliferation, metastasis, and delayed tumor growth (Fig. 7d).