TNF and glioblastoma: Transcriptome analysis of BT25 cells treated with TWEAK or TNFα, which preferentially activates the noncanonical or canonical NF-κB pathways respectively13, 14, revealed that the expression of NIK (MAP3K14) directly correlated with GBM cell invasion and was highly induced in response to TWEAK treatment but not TNFα treatment (Fig. 1B,C).