[37] studied the expression of GAL‐3 from NSCLC commercial cell lines (A549 and H1299) and revealed that spheroids express relatively high levels of this molecule over serial passages compared to monolayers cells acting as a cofactor by interacting with β‐catenin to augment the transcriptional activities of stemness‐related genes. This evidence concerns the gene LGALS3 and non-small cell lung carcinoma.