Importantly, a previous genome-wide survey of C. elegans with RNA knockdown technology reported that the reduced expression of SAMHD1 ortholog, ZK177.8, led to maternal sterility (47), implying that ZK177.8 is also involved in host early development as observed with SAMHD1 in AGS. This evidence concerns the gene SAMHD1 and Aicardi-Goutieres syndrome.