A series of recent studies reported that various SAMHD1 mutations are also found in multiple human cancers such as acute myeloid leukemia (31, 32), chronic lymphocytic leukemia (33, 34), and colon cancer (35, 36), supporting its potential roles in cell proliferation through the upregulation of intracellular dNTPs that is a well-known biochemical marker of cancer cells (37). The gene discussed is SAMHD1; the disease is cancer.