SAMHD1 and cancer: SAMHD1 is involved in various human diseases such as AGS neurodevelopmental genetic disorder (1, 2, 3, 4), cancers (36, 44, 51, 55), and HIV-1 infection in myeloid (6, 7, 8) cells as well as multiple cellular events, such as cell cycle progress (38), dsDNA break repair (41), DNA replication fork processing (42), and anticancer activity of araC (43, 56).