Furthermore, anaemia is highly prevalent, affecting nearly all HD patients, and given that clotting problems can lead to anemia in HD patients despite iron and erythropoietin supplementation, using the slope model might also be relevant to help prevent blood loss during HD (Babitt & Lin, 2012; Gafter‐Gvili et al., 2019; Lorentz et al., 2021; McMurray et al., 2012; Stauffer & Fan, 2014; Tanaka et al., 2018). The gene discussed is EPO; the disease is anemia (phenotype).