Another study of Hu revealed the pro-metastatic effect of lncRNAs in the TME of LUAD and they found that lncR00963 loaded in LUAD cell-derived extracellular vesicles fostered tumor growth and metastasis by facilitating Siah1 degradation but suppressing Zeb1 degradation [24]. The gene discussed is SIAH1; the disease is neoplasm.