To address the contribution of FGF9 in NASH‐driven HCC, FGF9 was specifically knocked down in the liver by infection with an adeno‐associated virus (AAV‐shFGF9), and the susceptibility to HCC was examined in the model of spontaneous NASH‐driven HCC, in which mice were treated with a HFHC diet and CCl4 after FGF9 knockdown. The gene discussed is FGF9; the disease is hepatocellular carcinoma.