The histological examination of FGF9 transgenic mice feeding with HFHC diet exhibited hepatic steatosis, inflammation and ballooning, in especial ECM accumulation were like those in the model of NASH induced by HFHC diet feeding and CCl4 treatment, indicating that the up‐regulation of hepatic FGF9 may be the cause of ECM accumulation and NASH‐driven HCC. Here, FGF9 is linked to hepatocellular carcinoma.