In recent years, researchers have increasingly recognized the important role of FGF9 in the development of several types of cancers, such as breast cancer, ovarian cancer, gastric cancer and colon cancer,[33, 37, 38, 39] however, it is still obscure whether FGF9 participates the NASH driven HCC. This evidence concerns the gene FGF9 and metabolic dysfunction-associated steatohepatitis.