ST14 and neoplasm: Of note, the latter can occur in two ways, with Matriptase on tumor cells cleaving targets on the surface of other cells of the tumor microenvironment [53], or with Matriptase from cells of the tumor microenvironment cleaving targets on the prospective tumor cells, as demonstrated here for outer and (pre-neoplastic) basal keratinocytes of the embryonic zebrafish epidermis.