In addition, based on bioinformatics analysis, molecular docking, and experimental verification, this study identified TREM2 as a potential target of GSP, regulating the PI3K/Akt pathway signaling activation, which played a crucial role in GSP-mediated M2a macrophage polarization and anti-inflammatory effects in a mouse model of LPS-induced ALI. The gene discussed is GNAS; the disease is acute respiratory distress syndrome.