Another element may form an interesting multiprotein complex with TFs of different families, such as SMADs, with other proteins such as Wilms tumor (WT) or the related early growth response (EGR) factors, and with the specificity protein (SP) and Kruppel-like family of TFs (−410 to −379) (Table 1) (Liu et al. 1996; Eisermann et al. 2008; Hill 2016). The gene discussed is TFF2; the disease is Nephroblastoma.