At week 4, a significant decline in SBP was observed for older patients (aged ≥ 75 years), patients with macro-albuminuria (urine albumin-creatinine ratio > 300 mg/g), and those with chronic kidney disease stage 3–4 (estimated glomerular filtration rate [eGFR] 15 to < 60 mL/min per 1·73 m2). This evidence concerns the gene ALB and chronic kidney disease.