The low level of activation of mTOR in the OM Ctrl group was associated with a low level of phosphorylation of p70S6K, a downstream signaling intermediate, but the changes in the ratio of p-p70S6K/p70S6K caused by HES administration were similar to those in the upstream intermediates in both muscles (Figure 5C,D). Here, RPS6KB1 is linked to ocular melanoma.