To determine whether important examples of such genes are direct targets of NF-κB as well as whether they are also directly de-repressed by H3K27me3 demethylation during MCL cell adhesion to stromal cells, we studied CCR7 (a chemokine receptor gene) and IL-10 (a cytokine gene), both of which are expressed at higher levels upon adherence of JeKo-1 MCL cells to stromal cells [48,51]. This evidence concerns the gene CCR7 and mantle cell lymphoma.