Insulin-like growth factor binding protein 5 (IGFBP5) is secreted by cancer-associated stromal cells and tumor cells of various types, and its cleavage by proteases such as MMP2 induces a release of IGFs that activate proliferative and antiapoptotic signaling pathways in diverse TME components, including tumor cells or other fibroblasts [50]. This evidence concerns the gene IGFBP5 and cancer.