Other alternate pathway inhibitory proteins, CFHR5 and factor H (F-H), were only increased in obese PCOS and both correlated with BMI, suggesting that obesity was causing their elevation; this is also perhaps an indication that in obese PCOS there is exacerbated alternate pathway activation, requiring more factors to damp it down. The gene discussed is FH; the disease is obesity due to melanocortin 4 receptor deficiency.