Among the positive regulators of the alternative pathway, factor B (F-B) was higher in obese PCOS (p < 0.0001, obese PCOS vs. control), but did not differ in nonobese PCOS compared to controls (Table 2); however, factor D (F-D) did not differ in either obese or nonobese PCOS compared to their respective controls. The gene discussed is LIF; the disease is polycystic ovary syndrome.