Recent publications derived from the analysis of GWAS human data have highlighted the involvement of BCNT/CFDP1 (Bucentaur/craniofacial development protein 1, hereafter referred to as CFDP1) in the determinants of risk factors for CAD, blood pressure, aortic diameter, neuroblastoma (NB) susceptibility and carotid intima–media thickness, raising the interest for a deeper understanding of the functional analysis of the CFDP1 gene in cardiovascular development and function [6,7,8,9,10]. The gene discussed is CFDP1; the disease is coronary artery disorder.