AHR and heart failure: Our data showed that cfdp1 morphants develop phenotypic abnormalities, such as pericardial edema, craniofacial malformations and hypoplastic swim bladder (the arrest of swim bladder inflation has been proposed to be a secondary event to heart failure, since in silent heart morphants that lack heart contractility, heart-specific constitutively activated AHR signaling and TCDD-exposed zebrafish models which develop heart failure, the swim bladder development is inhibited in the same manner [54]).