Moreover, tumor-secreted cytokines like CXCL8, PDGF, MIP1 and CSF3 increase the mobilization of neutrophils from the bone marrow and spleen, leading to an elevated neutrophil-to-lymphocyte ratio in both human [156,164,165,166] and mouse [22,167] studies. The gene discussed is CXCL8; the disease is neoplasm.