Upon infection, chemoattractants such as CXCL1, CXCL2 and IL-17 are produced in the lung, leading to further neutrophil recruitment and transmigration into the tissue, a process that is highly dependent on C-C chemokine receptor type 2 (CCR2)-positive blood monocytes [59,60]. The gene discussed is CXCL2; the disease is infection.