Since the WNT/β-catenin pathway was predicted to be dysregulated in our microarray and proteomics analysis, β-catenin was predicted to be an upstream regulator and WNT signalling has been implicated in various cancers, we selected this pathway to further explore its involvement in the mechanism of action of DCUN1D1 in PCa. The gene discussed is DCUN1D1; the disease is posterior cortical atrophy.