CUL5 and posterior cortical atrophy: We validated the role of cullin 3, cullin 4B and cullin 5 neddylation in the mechanism of DCUN1D1 in PCa, demonstrating preferential decreases in the cullin neddylation of cullins 1, 3, 4A, 4B and 5, and the deactivation of the WNT/β-catenin pathway via GSK-3 inactivation.