DCUN1D1 is an E3 ligase of the neddylation pathway and has been reported to be upregulated and associated with aggressive phenotypes and poor clinical outcomes in several types of cancer, particularly head and neck, lung, cervical and ovarian cancer as well as gliomas [3,4,5,8,9,10,11,12]. Here, DCUN1D1 is linked to central nervous system cancer.