LRRK2 and Parkinson disease: Of these proteins, LRRK2 stands out as being particularly prevalent, being one of the more frequently mutated genes associated with the condition-LRRK2 contains both GTPase domains; mutations are present both with autosomal dominant Parkinsonism as well as being linked with its development sporadically; its mutation rate accounts for around one percent and five percent in relation to familial Parkinsonism, respectively, making LRRK2 one of its more prominent genetic contributors to its association with Parkinsonism.