A study with a Caucasian patient population failed to prove the association between the two promoter SNPs (−308G>A and −238G>A) of TNFα and POAG [202], and a Japanese study revealed no significant association between three promoter SNPs (−308G>A, −857C>T and −863C>A) of TNFα and POAG, despite a potential interaction between OPTN and TNFα [203]. Here, OPTN is linked to open-angle glaucoma.