In a rat glaucoma model, adeno-associated virus 2-PARKIN (AAV2-PARKIN), which was used to overexpress PARKIN, led to a significant decrease in RGC loss and partial restoration of mitophagy levels under elevated IOP conditions, suggesting that clearance of impaired mitochondria through mitophagy is directly linked to better RGC survival [22]. This evidence concerns the gene PRKN and glaucoma.