Moreover, EVs in the plasma and CSF of patients suffering from neurodegenerative disorders such as Alzheimer’s disease (AD), PD, etc., are enriched with neurotoxic molecules including β-amyloid (Aβ), α-synuclein, and tau, whose origin are believed to be microglia and neuronal cells, and the uptake of toxic molecule-laden EVs to the local and distant neurons contributes to the neuronal loss, the characteristic feature of neurodegenerative disorders [118,119,120,121]. The gene discussed is MAPT; the disease is Alzheimer disease.