Moreover, the expression of urinary EVs’ chemokine (C-C motif) ligand 2 (CCL2) mRNA is shown to be significantly higher in IgA nephropathy (IgAN) patients as compared to other glomerulopathy controls, which is correlated with the tubular interstitial inflammation and C3 deposition, reflecting renal injury and impaired renal functions [161]. Here, CCL2 is linked to glomerular disorder.