In psoriasis, interferon α (IFN-α)-induced mast cell-derived EVs transfer cytoplasmic phospholipase A2 (PLA2) to nearby CD1a-expressing cells, thereby generating neo lipid antigens and their recognition by CD1a-reactive T-cells to induce the release of IL-22 and IL-17A, ultimately leading to skin inflammation [156]. The gene discussed is CD1A; the disease is psoriasis.