AKT1 and goblet cell carcinoma: Transcriptional dysregulation, potentially secondary to overactivation of p300/CBP through AKT phosphorylation, was among the top enriched pathways in appendiceal goblet cell adenocarcinomas as compared to other intestinal cancers, which indicates the significance of deregulated epigenetic modulation in the tumorigenesis of appendiceal cancers [51].