The Phosphatidylinositol 3-kinase/Protein Kinase B (PI3K/AKT) pathway, known to promote transcriptional competence by priming chromatin structure for subsequent transcriptional activity, is enriched in several appendiceal cancer subtypes across several studies, including appendiceal adenocarcinoma, appendiceal mucinous neoplasms, and appendiceal goblet cell adenocarcinomas [34,36,51,52]. Here, PIK3CA is linked to goblet cell carcinoma.