Indeed, intraperitoneal injection of ANP recombinant protein in DMXAA-treated colitis mice distinctly reversed the increased expression of cGAS and phosphorylation of STING, IRF3 and TBK1, while reducing body loss, colon shortening, DAI score and improving structural injury in a murine model of DSS-induced colitis. This evidence concerns the gene TBK1 and colitis.