CRYBB3 and amyotrophic lateral sclerosis: However, they found gene deletions (including Crystallin Beta B3-CRYBB3, Crystallin Beta B2-CRYBB2, LDL Receptor Related Protein 5 Like-LRP5L, Crystallin Beta B2 Pseudogene 1-CRYBB2P1), which were more common in ALS patients, compared to controls, suggesting CNVs as possibly ALS susceptibility factors [176].