C9orf72 and amyotrophic lateral sclerosis: A recent clinical study by Karch et al. further highlighted this problem with the discovery of ALS loci rs13302855 and rs3849942 (nearest gene, C9orf72; p = 0.03 for rs13302855 and p = 0.005 for rs3849942) [11] with the authors concluding sALS is a selectively pleiotropic, polygenic disorder.