They reported elevated INHAT repressor (NIR), nucleolar complex protein 2 homolog (NOC2L), programmed cell death 6-interacting protein (PDCD6IP), versican core protein (VCAN) proteins, and 11 proteins, which were reduced in ALS patients (such as alpha-1-antichymotrypsin, SERPINA3; receptor-type tyrosine-protein phosphatase zeta, PTPRZ1; complement C1q subcomponent subunit C, C1QC; coiled-coil domain-containing protein 19, mitochondrial, CCDC190), with researchers proposing that nucleolar stress impairment may impact sporadic ALS [233]. This evidence concerns the gene SERPINA3 and amyotrophic lateral sclerosis.