IL6 and amyotrophic lateral sclerosis: In 2017, a serum analysis of ALS patients showed elevations for malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG), the ratio of glutathione disulfide (GSSG)/glutathione (GSH), and IL6 and IL8, indicating a reduction in the total antioxidant status (TAS) of ALS patients [198].