OPTN and neurodegenerative disease: Furthermore, additional genes can also exacerbate non-neurodegenerative disease phenotypes, such as glaucoma (optineurin, OPTN) [13], Enterovirus-induced Type-1 diabetes (Peripherin, PRPH) [14], leukemia, or cancer (TATA-box-binding protein-associated factor 15, TAF15) [15,16].