BDNF and amyotrophic lateral sclerosis: No significant differences were detected, with authors attributing the findings to small sample size; however, 20 markers involved in angiogenesis and growth were reportedly enriched (such as fractalkine, Brain-derived neurotrophic factor BDNF, Epidermal Growth Factor EGF, Platelet-derived growth factor PDGF, Dickkopf WNT signaling pathway inhibitor 1, macrophage migration inhibitory factor, angiopoietin-2, or S100 calcium-binding protein B) and segregated with ALS [199].