In another study, using larger sample (CSF and serum) sizes (n = 105), researchers evaluated the potential of secreted macrophage and epithelial proteins, Chitotriosidase-1 (CHIT1), chitinase-3-like protein 1 (YKL-40), and monocyte chemoattractant protein-1 (MCP-1) as ALS prognostic biomarkers. The gene discussed is CHI3L1; the disease is amyotrophic lateral sclerosis.