In addition, the suppression of Neurofilament Heavy Chain (NEFH) or Neurofilament Modest Chain (NEFM) expression via a small group of ALS-linked miRNAs is shown to perturb cytoskeleton composition and disrupt axon structure and transport exhibiting impaired N-methyl-D-aspartate (NMDA)-mediated calcium influx [131]. The gene discussed is NEFH; the disease is amyotrophic lateral sclerosis.