Further in vitro studies demonstrated that LCA can decrease the expression of nuclear factor erythroid 2-related factor 2 (NRF2) and up-modulate Kelch-like ECH associating protein 1 (KEAP1), causing an imbalance between pro- and anti-oxidant enzymes, eventually impairing breast cancer cells proliferation [46]. The gene discussed is NFE2L2; the disease is breast cancer.