HAVCR2 and neoplasm: However, interestingly, a positive correlation was observed with tumor multifocality and the enrichment of PD1+CD38+Tim3+ CD8+ T cells (Pearson r = 0.5933, p = 0.0011 and Spearman r = 0.5257, p = 0.0049) at the tumor site in NMIBC (Figure 2C).