3.4. Transcriptome Analyses of Human Patients Shows a Correlation between Low MAGI1 Levels and Increased Tumor Mutational Burden (TMB), Homologous Recombination Deficiency (HRD), and AKT/MAPK Signaling. The gene discussed is MAGI1; the disease is hypoparathyroidism-retardation-dysmorphism syndrome.