Indeed, whereas we did not observe any genotype difference in Study 1, in accordance with previous studies by us [38] and others (e.g., [57,60,64,73,74]), reduced anxiety-like behaviors of Fmr1-KO mice were detected in the elevated plus maze and open field test in Study 2, as previously reported as well [10,58,64,65,75]. This evidence concerns the gene FMR1 and Anxiety.