BCL2 and lymphoma: In addition to COO, chromosomal translocations of BCL6, BCL2, and c-MYC are common cytogenetic abnormalities in DLBCL, and GCB lymphomas harboring these genetic lesions are called “double hit” lymphoma (c-MYC plus BCL2 or BCL6) or triple hit lymphoma (c-MYC plus BCL2 plus BCL6), respectively [3,6,7,8].