VEGFA and cancer: Moreover, VEGF was an independent prognostic factor for GC prognosis.[82] Cheng J[83] confirmed that COX-2 is involved in the immunosuppression of GC may involve PGE2 induce dendritic cells in the tumor microenvironment (TME) to lose function, which cannot effectively present tumor antigens, and ultimately T cells cannot recognize or kill cancer cells.