Survival analysis showed that the expression levels of CCNA1, EPHX1, CYP1B1, MYLK, DDR2, TGFB1, MMP2, SHH, CYP2C19, AKR1C3, MMP9, PKM, STS, and PTGS2 were significantly related to the prognostic outcomes of GC patients. The gene discussed is PKM; the disease is gastric cancer.