SHH and gastric cancer: To further confirm the efficacy of CXHO in treating GC, we selected 3 compounds with the highest degree values in CXHO for molecular docking, namely SIT, IH, and medicarpin, as they were found to have more genes in common with the 17 core genes (see Fig. S1, Supplemental Digital Content, http://links.lww.com/MD/J419, which demonstrates MMP2, PTGS2, CCNA1, SHH, TGFB1, and MMP9 were identified as the common genes of these 3 active compounds).