TP53 and cancer: IH was reported to have anti-inflammatory and antiproliferation activity in many cancers[42–45] and induce a cytotoxic effect by inhibiting ROS in tumor cells.[46] Medicarpin is a natural phytoestrogen usually found in extracts of various legumes,[47] and can exert anti-osteoclast and anti-inflammatory activity[48] as well as proapoptotic properties in leukemia cells.[49,50] SIT is one of the most plentiful natural plant sterols[51] and is involved in the activation of the tumor suppressor protein P53.