Abnormal PKM2 expression promotes malignant tumor metastasis and directly associated with clinical progression of the digestive system solid tumors.[74,75] In addition, malignant proliferation and poor prognosis of GC also directly associated with PKM2 expression.[76,77] Smyth EM[78] revealed that knock down PKM2 has suppressing G1-S phase transition of GC cells, particularly attenuates cell migration in vivo and vitro, increased autophagy, that is could contributed by mediating PI3K-Akt signaling pathway. The gene discussed is AKT1; the disease is gastric cancer.