Kaplan–Meier curves showed that the expression levels of CCNA1, EPHX1, CYP1B1, MYLK, DDR2, TGFB1, MMP2, SHH, CYP2C19, AKR1C3, MMP9, PKM, STS, and PTGS2 were significantly related to the survival of GC patients (Fig. 6), indicating the prognostic ability of these CXHO-related hub genes in GC. The gene discussed is SHH; the disease is gastric cancer.