PTGS2 and gastric cancer: To obtain the relevant target genes of CXHO in GC, we intersected the DEGs with target genes of CXHO and obtained 17 overlapping genes, namely, CCNA1, EPHX1, CYP1B1, MYLK, discoidin domain receptor 2 (DDR2), TGFB1, MMP2, FAP, CA9, SHH, CYP2C19, AKR1C3, PLA2G2A, MMP9, PKM, STS, and prostaglandin synthase COX-2 (PTGS2) (Fig. 4A).