Moreover, previous reports have suggested that overexpression of CA9 and HIF-1α is related with a poor prognosis of GC.[66–68] SHH/GLI signaling is closely related to embryonic development and tissue homeostasis.[69–71] Recent studies have suggested that the imbalance of this signal axis could contribute to tumor metastasis and drug resistance. The gene discussed is CA9; the disease is gastric cancer.