Compared to other liver disease etiologies, the NAFLD population has a much higher proportion of HCC in non-cirrhotic to cirrhotic livers.[16] Grohmann et al[18] suggested that obesity may cause NASH and HCC through different mechanisms, caused by a dissociation between the STAT-1 and STAT-3 activation pathways. The gene discussed is STAT3; the disease is metabolic dysfunction-associated steatotic liver disease.