NFKB1 and renal fibrosis: To sum up, inhibiting the activation of NF-kB signal pathway can slow down the progress of HN, which is embodied in the synergism between upstream and downstream of NF-kB signal pathway, which can inhibit renal fibrosis by interfering with excessive transcription from cytoplasm to nucleus, control inflammatory response, regulate immune factors and activate immune response, promote UA excretion and protect kidney.