M2-TAMs are known to promote angiogenesis, immunosuppression, and tumor invasion and metastasis.[62] Several studies have revealed that CAFs recruit monocytes to tumor cells and facilitate their differentiation into M2-TAMs through the CXCL12/CXCR4 pathway.[41,63,64] Additionally, Yang et al[42] reported that CAFs in hepatocellular carcinoma express high levels of endosialin (CD248), which interacted with CD68 to recruit monocytes and modulate GAS6 expression in CAFs, inducing M2 polarization. This evidence concerns the gene CXCL12 and hepatocellular carcinoma.