It dilates large and small coronary arteries through nitrate-like and potassium channel-opening effects, but is less likely to lower BP in patients with low to normal BP.[21–24] Nicorandil can be administered as a bolus or loading dose, as well as by continuous infusion, although there is only 1 successful case report of its use as a bolus in Kounis syndrome, in a patient with coronary vasospasm and hypotension.[25] Several other case reports have described using nicorandil in Kounis syndrome. The gene discussed is KCNA3; the disease is coronary vasospasm.