Immunotherapeutic approaches, including corticosteroids, calcineurin inhibitors, intravenous immunoglobulin, and anti-TNF agents, could be targeting the maternal immune system against early embryos or fetuses.[4–6] In this clinical study, the calcineurin inhibitor tacrolimus will be administered to Th1-dominant women with intractable infertility. The gene discussed is TNF; the disease is Infertility.